The opportunistic pathogenPseudomonas aeruginosacarries a secretable arachidonate 15-lipoxygenase
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چکیده
منابع مشابه
The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.
In mammals, lipoxygenases play key roles in inflammation by initiating the transformation of arachidonic acid into potent bioactive lipid mediators such as leukotrienes and lipoxins. In general, most bacteria are believed to lack lipoxygenases and their polyunsaturated fatty acid substrates. It is therefore of interest that an ORF (PA1169) with high homology to eukaryotic lipoxygenases was disc...
متن کاملALOX 15 ( arachidonate 15 - lipoxygenase )
Hugo: ALOX15 Other names: 15-LOX; EC 1.13.11.33; arachidonate omega 6-lipoxygenase; LOG15 Location: 17p13.3 Local order: Genes flanking ALOX15 in centromere to telomere direction on 17p13 are: MYBBP1A 17p13.3 MYB binding protein (P160) 1a, GGT6 17p13.2 homolog of gammaglutamyltransferase 6, LOC124974 17p13.2, thioredoxin 1 pseudogene 4, SMTNL2 17p13.2 smoothelin-like 2, ALOX15 17p13.2 arachidon...
متن کاملALOX 5 ( arachidonate 5 - lipoxygenase )
Hugo: ALOX5 Other names: 5-LO; EC 1.13.11.34; leukotriene A4 synthase; 5LPG; LOG5 Location: 10q11.2 Local order: Genes flanking ALOX5, in centromere to telomere direction on 10q11, are: OR6D1P 10q11.21 olfactory receptor, family 6, subfamily D, member 1 pseudogene. LOC643413 10q11.21 hypothetical protein LOC643413. OR13A1 10q11.21 olfactory receptor, family 13, subfamily A, member 1. ALOX5 10q1...
متن کاملArachidonate 15-Lipoxygenase Type B Knockdown Leads to Reduced Lipid Accumulation and Inflammation in Atherosclerosis
Inflammation in the vascular wall is important for development of atherosclerosis. We have shown previously that arachidonate 15-lipoxygenase type B (ALOX15B) is more highly expressed in human atherosclerotic lesions than in healthy arteries. This enzyme oxidizes fatty acids to substances that promote local inflammation and is expressed in lipid-loaded macrophages (foam cells) present in the at...
متن کاملArachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival.
Cancer stem cells (CSCs) are responsible for the initiation and maintenance of some types of cancer, suggesting that inhibition of these cells may limit disease progression and relapse. Unfortunately, few CSC-specific genes have been identified. Here, we determined that the gene encoding arachidonate 15-lipoxygenase (Alox15/15-LO) is essential for the survival of leukemia stem cells (LSCs) in a...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0307308101